Exploring the Usefulness of Carboxylic Acid Derivatives in Nucleophilic Acyl Substitution Reactions
نویسنده
چکیده
Carboxylic acid derivatives are the most widely occurring of all molecules, both in laboratory chemistry and in biological pathways. Specifically, acid derivatives are compounds in which the hydroxyl group of the carboxylic acid has been replaced by another acyl substituent that can act as a leaving group in nucleophilic acyl substitutions. These compounds can be acid halides, acid anhydrides, esters, thioesters, and amides. Some examples of carboxylic acid derivatives can be seen below in Figure 1.
منابع مشابه
Reactions of Carboxylic Acid Derivatives I
This is probably the single most important reaction of carboxylic acid derivatives. The overall transformation is defined by the following equation, and may be classified either as nucleophilic substitution at an acyl group or as acylation of a nucleophile. For certain nucleophilic reagents the reaction may assume other names as well. If Nuc-H is water the reaction is often called hydrolysis, i...
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